Projected Best-Selling Drugs 2025
Each year, some prescription medications make it to the top of the best-selling list in pharmacies around the country. Knowing the top sellers can help patients understand which treatments are most commonly used for which conditions. However, individual treatment decisions should always be personalized via a healthcare professional. Let’s look closer at the prescription drugs that are on their way to being the most popular in 2025.
Pembrolizumab (Keytruda)
Certain medications use the body’s powerful immune system to combat cancer cells, one of these medications is pembrolizumab. This drug, which has the brand name Keytruda, blocks a crucial protein that cancerous cells rely on.
The PD-1 protein allows tumors to go unnoticed by the immune system, and that makes it easier for them to replicate. If pembrolizumab can block the protein, cancer cells become “visible” to the immune system. It’s a drug that can treat melanoma, stomach cancer, lung cancer, and others.
Nivolumab (Opdivo)
Nivolumab, marketed as Opdivo, is also an immunotherapy drug that enhances the body’s immune response against cancer cells. It functions by inhibiting the PD-1 protein, allowing T-cells to recognize and attack cancer cells more effectively.
Opdivo is approved for treating various cancers, including non-small cell lung cancer, melanoma, renal cell carcinoma, and Hodgkin lymphoma.
Semaglutide (Ozempic)
Ozempic earned its place near the top of the best-selling drugs last year, and it’s poised to do the same this year. Semaglutide is a treatment for Type 2 diabetes that can help control blood sugar levels. It prevents the release of sugars from the liver and slows down how food makes it through your digestive system.
Despite being created for treating diabetes, semaglutide is commonly used for weight loss. The drug mimics a natural hormone called glucagon-like peptide-1, which can help regulate your digestion and appetite. It slows down how quickly your body breaks food down, prompting you to feel fuller for longer.
Tirzepatide (Mounjaro)
Tirzepatide is similar to semaglutide and appears to be the latter’s competition for the top diabetes and weight loss drug this year. Mounjaro, which is tirzepatide’s brand name, is an injection that treats Type 2 diabetes by controlling blood sugar levels. It’s a glucose-dependent insulinotropic polypeptide (GIP) receptor as well as a glucagon-like peptide-1 receptor agonist.
Because it impacts the hormones that manage your appetite, tirzepatide is an effective weight loss option. Additionally, it can treat moderate to severe obstructive sleep apnea.
Dupilumab (Dupixent)
Dupilumab is a biologic drug that helps to moderate inflammatory responses that cause conditions like eczema, chronic rhinosinusitis that presents with nasal polyps, and asthma. It’s an effective medication because it targets and blocks two important proteins that cause these inflammatory responses: IL-4 and IL-13.
Dupilumab can reduce the chest tightness and wheezing associated with asthma and can assist in treating eosinophilic esophagitis, a condition in which there are high levels of blood cells in the esophagus. It’s also a good treatment option for prurigo nodularis, which is a skin condition that causes very itchy and hard bumps.
Risankizumab (Skyrizi)
Another medication that focuses on moderating the body’s inflammatory response is risankizumab, which goes by the brand name Skyrizi. This is an injection that is often prescribed for the treatment of plaque psoriasis, Crohn’s disease, and psoriatic arthritis.
The medication is made from living organisms or their products, making it a biologic drug. It inhibits the IL-23 protein, which plays a role in how the body’s immune system functions as well as in its inflammatory response. By blocking this protein, the drug can reduce swelling and other symptoms.
Ustekinumab (Stelara)
Yet another medication is ustekinumab, sold under the brand name Stelara, a monoclonal antibody doctors prescribe to treat autoimmune conditions such as psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis.
It targets interleukins IL-12 and IL-23, cytokines involved in inflammatory and immune responses. By inhibiting these cytokines, Stelara reduces inflammation and alleviates symptoms of these difficult conditions.
Apixaban (Eliquis)
Apixaban is an anticoagulant, which means it thins the blood. It’s a medication that can help prevent blood clots and strokes. Eliquis is its brand name, and it’s prescribed for people with atrial fibrillation or deep vein thrombosis. It can also be a treatment option for those with pulmonary embolisms.
The medication functions by blocking factor Xa, which is an essential ingredient in the formation of a clot. Apixaban slows down the clotting process. It’s often prescribed for people right after they’ve had a knee replacement because this surgery increases the risk of clots.
Aflibercept (Eylea)
Aflibercept, known commercially as Eylea, is an anti-angiogenic agent that patients use to treat age related macular degeneration, diabetic macula edema, retinal vein occlusion, and other eye diseases.
It inhibits vascular endothelial growth factor (VEGF), which is a protein that promotes the growth of abnormal blood vessels in the eye. By blocking VEGF, Eylea helps prevent vision loss and has even become a leading therapy in ophthalmology.
Bictegravir/Emtricixtabine/Tenofovir Alafenamide (Biktarvy)
Biktarvy is a combination antiretroviral medication used for the treatment of HIV-1 infection. It combines three main ingredients: bictegravir, an integrase strand transfer inhibitor; emtricitabine; and tenofovir alafenamide, both nucleoside reverse transcriptase inhibitors.
This once-daily tablet offers people living with HIV an effective treatment option. Although it’s not a cure, it can help those with HIV gain some normalcy.
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